F
Fabio Di Domenico
Researcher at Sapienza University of Rome
Publications - 117
Citations - 11953
Fabio Di Domenico is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Oxidative stress & Alzheimer's disease. The author has an hindex of 44, co-authored 107 publications receiving 9793 citations. Previous affiliations of Fabio Di Domenico include University of Kentucky.
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Journal ArticleDOI
Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target
Cristiano Spadaccio,Cristiano Spadaccio,Raffaella Coccia,Marzia Perluigi,Gilda Pupo,Maria Eugenia Schininà,Alessandra Giorgi,Carla Blarzino,Francesco Nappi,Fraser W.H. Sutherland,Massimo Chello,Fabio Di Domenico +11 more
TL;DR: This study finds increased oxidative damage to protein as indexed by the total carbonyl levels and total protein-bound HNE and the aortic diameter supports the involvement of oxidative stress in the pathogenesis of AAA and might provide a further degree of knowledge in the cause-effect role.
Journal ArticleDOI
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome.
Sara Pagnotta,Antonella Tramutola,Eugenio Barone,Fabio Di Domenico,Valeria Pittalà,Loredana Salerno,Valentina Folgiero,Matteo Caforio,Franco Locatelli,Stefania Petrini,D. Allan Butterfield,Marzia Perluigi +11 more
TL;DR: In this article , the role of BACH1/NRF2 ratio in the regulation of the anti-oxidant response was investigated, and the authors proposed their antithetical relation as a valuable target for a therapeutic strategy to test drugs able to exert neuroprotective effects in aging and neurodegenerative diseases.
Journal ArticleDOI
Erratum: Glutathionylation of the pro-apoptotic protein p53 in alzheimer's disease brain: Implications for AD pathogenesis (Neurochemical Research (2009) 34 (727-733) DOI 10.1007/s11064-009-9924-9
Posted ContentDOI
Novel therapeutic targets to mitigate early neuronal dysfunction and cognitive deficits in tauopathy
Shon A. Koren,Matthew Hamm,Ryan Cloyd,Sarah N. Fontaine,Emad Chishti,Chiara Lanzillotta,Fabio Di Domenico,Nicholas T. Seyfried,Duc M. Duong,David K. Powell,Moriel H. Vandsburger,Anika M.S. Hartz,John Koren,Jeffrey M. Axten,Nicholas J. Laping,Jose F. Abisambra +15 more
TL;DR: Early stage tau transgenic mice are treated with a multi-target kinase inhibitor to identify novel substrates that contribute to cognitive impairment and exhibit therapeutic potential and a cluster of preserved pathways shared with human tauopathy with striking potential for broad multi- target kinase intervention is identified.
Book ChapterDOI
Peripheral Biomarkers of Oxidative Stress in Alzheimer’s Disease
TL;DR: Findings support the view that OS is an early event in the pathogenesis of AD and thus assessment of the presence of peripheral oxidative damage that correlates with the occurrence of the disease is intriguing.