Fangxia Guan

TL;DR: In this paper, the status of aging research and the development of potential drugs for aging-related diseases, such as metformin, rapamycin, resveratrol, senolytics, as well as caloric restriction, are summarized.

TL;DR: In vivo, MALAT1 overexpression enhanced tumors’ TMZ resistance and upregulated ZEB1 expression and decreased the sensitivity of resistant glioma cell lines to TMZ by regulating Z EB1.

TL;DR: In vivo tests indicated that the injectable HA/SA scaffold not only protected the injected human umbilical cord mesenchymal stem cells so that they could maintain a higher survival ratio, but it also contributed to the regeneration of endogenous nerve cells.

TL;DR: Beyond demonstrating a role for histone lactylation in a neurodegenerative disease and showing how multi-layered regulatory impacts attend altered glucose metabolism in microglia, this study illustrates that disrupting a positive feedback loop may support the development of innovative AD therapies.

TL;DR: It is reported that resveratrol facilitates hUC‐MSCs engraftment in the hippocampus of AD mice and resver atrol enhances the therapeutic effects of hUC-MSCs in this model as demonstrated by improved learning and memory in the Morris water maze, enhanced neurogenesis and alleviated neural apoptosis in the hippocampal of the AD mice.