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Fatemeh Momen-Heravi
Researcher at Columbia University
Publications - 87
Citations - 4311
Fatemeh Momen-Heravi is an academic researcher from Columbia University. The author has contributed to research in topics: Microvesicles & Cancer. The author has an hindex of 27, co-authored 71 publications receiving 3269 citations. Previous affiliations of Fatemeh Momen-Heravi include Columbia University Medical Center & University of Massachusetts Medical School.
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Journal ArticleDOI
Current methods for the isolation of extracellular vesicles.
Fatemeh Momen-Heravi,Leonora Balaj,Sara Alian,Pierre-Yves Mantel,Allison E. Halleck,Alexander J. Trachtenberg,Cesar E. Soria,Shanice Oquin,Christina M. Bonebreak,Elif Saracoglu,Johan Skog,Winston Patrick Kuo +11 more
TL;DR: The latest advances in methods of isolation methods and production of clinical grade EVs are discussed, as well as their advantages and disadvantages, and the justification for their support and the challenges that they encounter.
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Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90
TL;DR: It is shown that exosomes isolated from sera of chronic HCV infected patients or supernatants of J6/JFH1-HCV-infected Huh7.5 cells contained HCV RNA, and exosome-loading with a miR-122 inhibitor, or inhibition of HSP90, vacuolar H+-ATPases, and proton pumps significantly suppressed exOSome-mediated HCV transmission to naïve cells.
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Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS
TL;DR: It is shown that the number of exosomes significantly increases in the sera of healthy individuals after alcohol binge drinking and in mice after binge or chronic alcohol consumption, and hepatocyte-derived miRNA-122 can reprogram monocytes inducing sensitization to LPS.
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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
Fatemeh Momen-Heravi,Banishree Saha,Karen Kodys,Donna Catalano,Abhishek Satishchandran,Gyongyi Szabo +5 more
TL;DR: Elevated level of EVs/exosomes and exosome-associated miRNAs can serve as potential diagnostic markers for AH and may facilitate development of novel strategies for diagnostics, monitoring, and therapeutics of AH.
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Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages
TL;DR: It is shown that B cell-derived exosomes can function as vehicles to deliver exogenous miRNA-155 mimic or inhibitor into hepatocytes or macrophages, respectively and resulted in functionally more efficient inhibition and less cellular toxicity compared to conventional transfection methods.