Showing papers by "Federico Bozzetti published in 2002"
TL;DR: HPN may benefit a limited percentage of patients who may survive longer than the time allowed by a condition of starvation and depletion, and there is some evidence that QoL remains stable for some months and acceptable for the patients.
181 citations
TL;DR: There was a limited relative risk reduction in the patients receiving adjuvant therapy (17% in DFS and 7% in OS) and the data suggest that D2 surgery may have a favourable impact on OS.
135 citations
TL;DR: A positive relation was demonstrated between these types of cancer and the prevalence and severity of weight loss and the ECOG study found that patients with favorable subtypes of non-Hodgkin’s lymphomas, breast cancer, acute non-lymphocytic leukemia, and sarcomas had the lowest prevalence ofWeight loss.
61 citations
TL;DR: A lymphadenectomy including more than 25 lymph nodes is suggested, provided that there is a low risk of operative mortality.
Abstract: Aims: Surgeons involved in the treatment of gastric cancer are interested in the extent of lymphadenectomy as the latter may not only influence the reliability of the tumour, node and metastasis classification but also be relevant for the long-term oncological outcome. The purpose of the study was to evaluate the prognostic role of the number of resected lymph nodes (as an indicator of the scope of lymphadenectomy) and of the number of metastatic lymph nodes on the long-term mortality for all causes and to provide clinicians with estimates of predictive survival probabilities. Methods: The study involved 615 cancer patients subjected to a curative (R0) subtotal or total gastrectomy in a randomized Italian trial. According to the trial protocol, a D2 lymphadenectomy had been advised. The number of resected and metastatic lymph nodes was analysed as a continuous variable in multiple Cox models. Results: There was no difference in operative mortality (about 1.8%) according to the number of lymph nodes in the specimen (≤15, 16–25, >25). The risk of long-term death for all causes tended to decrease with increasing number of resected lymph nodes up to about 25, and then could be considered stable for wider lymphadenectomies. An increasing risk of death for all causes was associated with an increasing number of metastatic lymph nodes; the risk could be considered stable for more than 20 metastatic lymph nodes. Conclusions: A lymphadenectomy including more than 25 lymph nodes is suggested, provided that there is a low risk of operative mortality.
60 citations
TL;DR: Local response to preoperative RT/CT was highly satisfactory and allowed conservative surgery in 81% of patients and Optimization of the combined therapy could achieve even better results.
Abstract: There is no consensus about the role of preoperative radiotherapy (RT) and chemotherapy (CT) in patients with resectable cancer of the distal rectum. This study analyzed the local clinical and pathologic response in patients receiving preoperative RT/CT for rectal cancer. Thirty-two consecutive patients with a palpable adenocarcinoma of the rectum received preoperative RT (45 Gy in 25 fractions over 5 weeks), plus continuous chemotherapy with doxifluridine and leucovorin or 5-fluorouracil by continuous intravenous infusion during RT. Surgery was performed 8 weeks later. The Wilcoxon andχ
2 tests were used for data analysis. Twelve patients had mild gastrointestinal toxicity, only one of whom required interruption of therapy. The tumor shrank to 57.8% of its original size, and at the echoendoscopy (u) there was a 58.7% decrease of the maximum diameter (P<.001). Downstaging from uT3 and uT2 to
33 citations