Federico Micheli

TL;DR: Despite evidence of a higher α-SYN burden in the upper gut, only constipation and defecatory dysfunction were prominent premotor GIS of PD.

TL;DR: The efficacy and safety of preladenant in patients with Parkinson's disease and motor fluctuations who were receiving levodopa and other antiparkinsonian drugs were assessed.

TL;DR: Cantillon and Onofrj as mentioned in this paper presented the results of a study at the University of South Florida, Tampa, FL, USA (Prof R A Hauser MD); Merck, Whitehouse Station, NJ, USA(M Cantillon MD, S Huyck DrPH, K Wolski MD); Coalition Against Major Diseases, Critical Path Institute, Rockville, MD, USA; Laval University, Quebec, QC, Canada (Prof E Pourcher MD); Hospital de Clinicas Jose de San Martin, Buenos Aires, Argentina (Prof F Micheli

TL;DR: Salivary composition is abnormal in PD and is not affected by levodopa treatment and domperidone treatment, while basal and reflex salivary flow rate is significantly lower in PD patients in the off state compared to controls.

TL;DR: The most common causes of HT in a series of 29 patients with Holmes tremor were vascular lesions and the most common lesion topography was mesencephalic, thalamic, or both.