The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

THIS text-book of pharmacognosy has already found wide recognition among teachers and students of pharmacy. Its subject matter has grown from a laboratory manual intended for use in practical classes, and now comprises the requirements for the Chemist and Druggist Qualifying Examination of the Pharmaceutical Society of Great Britain. A Textbook of Pharmacognosy By T. C. Denston. Fourth edition. Pp. xviii + 594. (London: Sir Isaac Pitman and Sons, Ltd., 1945.) 27s. 6d. net.

/pdf/a-textbook-of-pharmacognosy-33ag9rvlzo.pdf

A Textbook of Pharmacognosy

Woody Plants of Ghana and Their Uses@@@Woody Plants of Ghana, with Special Reference to Their Uses

Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (syn. Waltheria americana): a review.

The use of plant to meet health-care needs has greatly increased worldwide in the recent times. The search for new plant-derived bioactive agents that can be explored for the treatment of drug-resistant malaria infection is urgently needed. Thus, we evaluated the antimalarial activity of three medicinal plants used in Nigerian folklore for the treatment of malaria infection. A modified Peter’s 4-day suppressive test was used to evaluate the antimalarial activity of the plant extracts in a mouse model of chloroquine-resistant Plasmodium berghei ANKA strain. Animals were treated with 250, 500, or 800 mg/kg of aqueous extract. It was observed that of all the three plants studied, Markhamia tomentosa showed the highest chemosuppression of parasites of 73 % followed by Polyalthia longifolia (53 %) at day 4. All the doses tested were well tolerated. Percentage suppression of parasite growth on day 4 post-infection ranged from 1 to 73 % in mice infected with P. berghei and treated with extracts when compared with chloroquine diphosphate, the standard reference drug which had a chemosuppression of 90 %. The percentage survival of mice that received extract ranged from 0 to 60 % (increased as the dose increases to 800 mg/kg). Phytochemical analysis revealed the presence of tannins, saponins, and phenolic compounds in all the three plants tested.

/pdf/phytochemical-screening-and-in-vivo-antimalarial-activity-of-58o4mg0bzm.pdf

Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria

This study involves the phytochemical screening and ethnomedicinal survey of twenty-three medicinal plants belonging to thirteen families commonly found in Nigeria. Semi-structured interviews and discussions with selected informants were adapted to collect ethnobotanical information on the plants. It was discovered that all of them possess alkaloids, tannins and saponin. Steroid is present in only twelve of the plant species, only five have phlobatannin; terpene is present in twenty of the plants, flavonoid is present in nineteen of the plants, while cardiac glycoside is present in sixteen of the species. Leea guineensis and Uvaria chamae were the only plants among the 23 plant samples that contain all the eight phytochemicals tested. The phytochemical present in the samples were juxtaposed with their ethnomedicinal significance, and from this, several suggestions were deduced on the secondary metabolites responsible for the pharmacological actions of the plants.  Conclusively, it could be said that the ethnomedicinal significance of the selected plants for this study corresponds to the pharmacological actions of the secondary metabolites they contain.

	 

	Key words: Phytochemical, ethnomedicinal, medicinal plants, bioprospecting.

https://www.africaneditors.org/journal/JMPR/full-text-pdf/80266-127538

Phytochemical and ethnobotanical study of some selected medicinal plants from Nigeria

Phytochemical screening and ethnomedicinal survey of twenty-two medicinal plants distributed in fifteen different families were carried out in order to know the distribution of secondary metabolites and the diseases being treated with these plants. It was discovered that alkaloids, tannins and saponin were present in all.  Flavonoid was absent only in Peperomia pellucida; five out of these plants lack terpene, ten of them have steroid; eleven of them have cardiac glycosides while only four of these twenty-two have phlobatannin. The ethnomedicinal survey revealed a wide range of human ailments being treated with these plants, ranging from eye infections, respiratory infections, inflammations, urinary diseases, jaundice, anaemia, arthritis to diabetes and dysentery. This study therefore, justifies the ethnobotanical significance of the plants by the presence of secondary metabolites, which if extracted, can be of significant medicinal usefulness in the synthesis of bioactive drugs. Therefore, the findings of this study are recommended for further screening to identify specific photochemical compounds of medicinal significance for bioprospecting and pharmaceutical production.

	 

	Key words: Phytochemical, ethnomedicinal, medicinal plants, secondary metabolites.

https://www.academicjournals.org/article/article1380785597_Omotayo and Borokini.pdf

Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria

Aim: To determine the nutritional and anti-nutritional compositions of Brillantaisia patula leaves using standard analytical methods. Place and Duration of Study: The proximate, mineral and anti-nutritional compositions were determined in the chemistry laboratory of Ekiti State University, Ado – Ekiti while the amino acid was determined at the Analytical Laboratory of Multi-Environmental Management Consultant, Lagos, Nigeria. Methodology: The proximate composition was carried out using the methods of Association of Official Chemists (AOAC) while mineral and anti-nutritional compositions were determined using standard analytical methods. Amino acid analysis was carried out through ion exchange chromatography (IEC) using the Technicon Sequential Multisample (TSM) Amino Acid Analyser. Results: The proximate composition ranged from 3.18% (crude fat) to 38.6% (carbohydrate). The major mineral constituents of the sample were: P (1061 mg/100g), K (874 mg/100g), Ca (799 mg/100g), Na (82.6 mg/100g) and Mg (24.3 mg/100g) while the minor mineral constituents were: Fe Original Research Article Akinsola et al.; APRJ, 8(4): 63-73, 2021; Article no.APRJ.78106 64 (26.9 mg/100g), Zn (7.7 mg/100g) and Mn (6.05 mg/100g). The evaluated anti-nutritional contents were: 6.71 mg/g oxalate, 5.37 % saponin, 1.0 mg/100g tannin and 4.72 mg/kg cyanide. Additional results showed that the leaves contained eighteen amino acids with values ranging from 0.504 g/100g cp (tryptophan) to 14.0 g/100g cp (glutamic acid). The value of the total essential amino acids (TEAA) with histidine was 45.6g/100g cp while the total non-essential amino acid (TNEAA) was evaluated to be 46.5 g/100g cp. Conclusion: Brillantaisia patula leaves could be utilized as a good source of essential amino acids and important mineral elements.

Felix Oluwafemi Omotayo

Papers

Phytochemical and ethnobotanical study of some selected medicinal plants from Nigeria

Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria

Nutritional Evaluation of Brillantaisia patula Leaves