The invention relates to bicyclol phosphate ester (salt), a preparing method and preparation thereof, and application of the bicyclol phosphate ester (salt) to the preparing of anti-inflammation drugs. The formula (I) of the bicyclol phosphate ester (salt) is as shown in the description, wherein M1 and M2 respectively independently represent H, metal ions, ammonium ion (NH4+) or amino. Bicyclol phosphate ester is prepared by the phosphorylation reaction of bicyclol and phosphorylation reagent in the presence of catalyst and acid-binding agent, and the bicyclol phosphate ester salt is prepared by allowing the bicyclol phosphate ester to react with alkali or salt. The bicyclol phosphate ester (salt) and the preparing method thereof have the advantages that phosphate groups are introduced into the molecule structure of the bicyclol, the lipo-hydro partition coefficient of the drugs is improved by the high electronegativity, namely high hydrophilicity of the phosphate groups, and drug water solubility is increased under the premise that the activity and safety of the bicyclol are unaffected; the prepared bicyclol phosphate ester (salt) can increase the targeting effect of the bicyclol on the liver, improve the administration route, and prolong the in-vivo retention time of the drugs.

Bicyclol phosphate ester compound and preparing method, preparation and application thereof

The invention relates to a flavonoid derivative containing a flavonoid that is coupled to an alkylene group via an ether bond, said alkylene group having an adhesion group for adhesion onto a dental surface. The flavonoid derivative has a long-term suppressing effect on the dental disease-causing formation of biofilm on the dental surfaces treated with the flavonoid derivative. The invention further relates to a kit for producing such a flavonoid derivative, and to the use of same.

Flavonoid derivative for treating dental caries

The invention relates to the field of medicine and pharmacology, in particular to medical application of acacetin The acacetin can be used for ulcerative colitis preventing

Application of acacetin in preparing of ulcerative colitis preventing medicine or food

The invention discloses application of robinin-7-O-glucuronide. A compound has cardioprotective effect activity, so that the robinin-7-O-glucuronide can be used as a lead compound with a cardioprotective effect.

Application of robinin-7-O-glucuronide

Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.

https://hub.hku.hk/bitstream/10722/221223/1/9900007.pdf

Feng Lin

Papers

Water-Soluble Derivatives and Prodrugs of Acacetin and Methods of Making and Using Thereof