F
Ferid Murad
Researcher at University of Texas Health Science Center at Houston
Publications - 176
Citations - 22449
Ferid Murad is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Nitric oxide & GUCY1A3. The author has an hindex of 74, co-authored 173 publications receiving 21993 citations. Previous affiliations of Ferid Murad include Shanghai University & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations.
TL;DR: Nitric oxide gas increased guanylate cyclase activity in soluble and particulate preparations from various tissues and it is proposed that various nitro compounds and those capable of forming NO in incubations activate guanylated cyclase through a similar but undefined mechanism.
Journal ArticleDOI
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
Jennifer S. Pollock,Ulrich Förstermann,Jane A. Mitchell,Timothy D. Warner,Harald H.H.W. Schmidt,Masaki Nakane,Ferid Murad +6 more
TL;DR: The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor has been purified from cultured and native (noncultured) bovine aortic endothelial cells and required L-arginine, NADPH, Ca2+, calmodulin, and 5,6,7,8-tetrahydrobiopterin for full activity.
Journal ArticleDOI
Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.
Robert M. Rapoport,Ferid Murad +1 more
TL;DR: The hypothesis that vascular smooth muscle relaxation induced by some agents is dependent on the presence of the endothelium and is mediated through the formation of an endothelial factor that increases cGMP levels in smooth muscle is supported.