F
Fernando Rodriguez
Researcher at Autonomous University of Barcelona
Publications - 77
Citations - 3646
Fernando Rodriguez is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Virus & African swine fever virus. The author has an hindex of 32, co-authored 69 publications receiving 3156 citations. Previous affiliations of Fernando Rodriguez include Scripps Research Institute.
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DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction.
TL;DR: Ubiquitination therefore may improve DNA immunization, but caution is warranted, since immunity to many microbes depends on induction of good humoral immunity, and it is shown here that this may be prevented by ubiquitination of the encoded protein.
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Rapid on/off cycling of cytokine production by virus-specific CD8 + T cells
TL;DR: The ability to turn cytokines on and off while maintaining intracellular stores of perforin shows the versatility of the cellular immune response and provides a mechanism for maintaining effective immune surveillance while reducing systemic immunopathology.
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Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
Martin Villalba,Kun Bi,Fernando Rodriguez,Yoshihiko Tanaka,Stephen P. Schoenberger,Amnon Altman +5 more
TL;DR: Evidence is provided that lipid raft polarization to the IS depends on an intracellular pathway that involves Vav1, Rac, and actin cytoskeleton reorganization and Vav is necessary, but not sufficient, to regulate lipid rafts clustering and polarization at the IS, suggesting that additional signals are required.
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An autologous oral DNA vaccine protects against murine melanoma
Rong Xiang,Holger N. Lode,Ta Hsiang Chao,J. Michael Ruehlmann,Carrie S. Dolman,Fernando Rodriguez,J. Lindsay Whitton,Willem W. Overwijk,Nicholas P. Restifo,Ralph A. Reisfeld +9 more
TL;DR: It is demonstrated that peripheral T cell tolerance toward murine melanoma self-antigens gp100 and TRP-2 can be broken by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to minigenes encoding peptide epitopes gp100(25-33) and TRp-2.
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The African swine fever virus proteins p54 and p30 are involved in two distinct steps of virus attachment and both contribute to the antibody-mediated protective immune response
Paulino Gómez-Puertas,Fernando Rodriguez,J.M. Oviedo,Alejandro Brun,Covadonga Alonso,José M. Escribano +5 more
TL;DR: It is strongly suggested that proteins p54 and p30 mediate specific interactions between ASF virus and cellular receptors and that simultaneous interference with these two interactions has a complementary effect in antibody-mediated protection.