Finn P. Reinholt

TL;DR: The results thus support the hypothesis that osteoclasts when resorbing bone are anchored by osteopontin bound both to the mineral of bone matrix and to a vitronectin receptor on the osteoclast plasma membrane.

TL;DR: In this paper, the authors show that mice lacking a functional fibromodulin gene exhibit an altered morphological phenotype in tail tendon with fewer and abnormal collagen fiber bundles, and they demonstrate that the orchestrated action of several leucine-rich repeat glycoproteins/proteoglycans influence the architecture of collagen matrices.

TL;DR: Changes in the fiber structure and arrangement, as well as increased amounts of interfibrillar GAG, appear to be characteristic morphological features in Achilles tendons with long-standing achillodynia and ultrasonographic widening, which may indicate that achillingnia is due to local disturbances in connective tissue metabolism or circulation or to both.

TL;DR: The observations corroborate previous findings that the osteoclast is attached via an integrin to osteopontin on the bone surface and show that bone sialoprotein and fibronectin can mediate osteOClast binding in vitro, but such a role in vivo is not supported by the immunocytochemical observations.

TL;DR: Two patients who underwent pancreatic transplantation with poor HLA matching are reported on, and the degree of immunosuppression required to prevent rejection is sufficient to prevent autoimmune damage to the pancreatic graft.