Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Let's read! We will often find out this sentence everywhere. When still being a kid, mom used to order us to always read, so did the teacher. Some books are fully read in a week and we need the obligation to support reading. What about now? Do you still love reading? Is reading only for you who have obligation? Absolutely not! We here offer you a new book enPDFd the perception of the visual world to read.

The Perception of the Visual World. By James J. Gibson. U.S.A.: Houghton Mifflin Company, 1950 (George Allen & Unwin, Ltd., London). Price 35s.

Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions1-3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes appropriate for classical brain mapping4 (the median neuroimaging study sample size is about 25), but potentially too small for capturing reproducible brain-behavioural phenotype associations5,6. Here we used three of the largest neuroimaging datasets currently available-with a total sample size of around 50,000 individuals-to quantify BWAS effect sizes and reproducibility as a function of sample size. BWAS associations were smaller than previously thought, resulting in statistically underpowered studies, inflated effect sizes and replication failures at typical sample sizes. As sample sizes grew into the thousands, replication rates began to improve and effect size inflation decreased. More robust BWAS effects were detected for functional MRI (versus structural), cognitive tests (versus mental health questionnaires) and multivariate methods (versus univariate). Smaller than expected brain-phenotype associations and variability across population subsamples can explain widespread BWAS replication failures. In contrast to non-BWAS approaches with larger effects (for example, lesions, interventions and within-person), BWAS reproducibility requires samples with thousands of individuals. 

/pdf/reproducible-brain-wide-association-studies-require-3qa0wl93.pdf

Reproducible brain-wide association studies require thousands of individuals

The aim of this paper was to review the literature on adolescent psychiatric disorders related to the COVID-19 pandemic and lockdown Stressful life events, extended home confinement, brutal grief, intrafamilial violence, overuse of the Internet and social media are factors that could influence the mental health of adolescents during this period The COVID-19 pandemic could result in increased psychiatric disorders such as Post-Traumatic Stress, Depressive, and Anxiety Disorders, as well as grief-related symptoms Adolescents with psychiatric disorders are at risk of a break or change in their care and management; they may experience increased symptoms The COVID-19 pandemic and lockdown may have a negative impact on the mental health of adolescents, although there is still no data on the long term impact of this crisis Adolescents' individual, familial, and social vulnerability, as well as individual and familial coping abilities, are factors related to adolescent mental health in times of crisis Adolescents are often vulnerable and require careful consideration by caregivers and healthcare system adaptations to allow for mental health support despite the lockdown Research on adolescent psychiatric disorders in times of pandemics is necessary, as such a global situation could be prolonged or repeated

/pdf/adolescent-psychiatric-disorders-during-the-covid-19-24gsf08u19.pdf

Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown.

The everyday environment brings about many competing inputs from different modalities to our sensory systems. The ability to filter these multisensory inputs in order to identify and efficiently utilize useful spatial cues is necessary to detect and process the relevant information. In the present study, we investigate how feature-based attention affects the detection of motion across sensory modalities. We were interested to determine how subjects use intramodal, crossmodal auditory, and combined audiovisual motion cues to attend to specific visual motion signals. The results show that in most cases, both visual and auditory cues enhance feature-based orienting to a visual motion pattern that is presented among distractor patterns. Furthermore, in many cases, detection of transparent motion patterns was significantly more accurate after combined visual-auditory than unimodal attention cues. Whereas previous studies have shown crossmodal effects of spatial attention, our results demonstrate a spread of crossmodal feature-based attention cues, which have been matched for the detection threshold of the visual target. These effects were evident in comparisons between cued and uncued conditions, as well as in analyses comparing the effects of valid vs. invalid cues.

/pdf/cross-modal-cue-effects-in-motion-transparency-processing-3jprgvbb4p.pdf

Cross-Modal Cue Effects in Motion Transparency Processing

Cannabis is one of the most widely used psychoactive substances. Initiation of cannabis use is typically during adolescence, a developmental period of marked brain development that supports the maturation of cognitive and affective behaviors. CB1 receptors (the primary binding sites for the psychoactive component in cannabis, Δ9 tetrahydrocannabinol) undergo maturational changes during adolescence and are widely distributed in developmentally sensitive brain regions. To this end, adolescent cannabis use has been associated with several developmental outcomes in cognition and brain structure and function, which could reflect a neurodevelopmental sensitivity to cannabis. However, a growing literature highlights a potential confounding role of sociodemographic, personality, and psychiatric substance use risk factors on behavioral and brain outcomes, limiting the interpretation of direct developmental effects of cannabis on neurocognitive development. Future directions to help untangle predictors and outcomes of cannabis use on adolescent neurocognitive development are discussed.

Finnegan J. Calabro

Papers

Cross-Modal Cue Effects in Motion Transparency Processing

Adolescent neurocognitive development and cannabis use