F
Fiona E. Harrison
Researcher at Vanderbilt University Medical Center
Publications - 60
Citations - 3710
Fiona E. Harrison is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Ascorbic acid & Vitamin C. The author has an hindex of 29, co-authored 60 publications receiving 3011 citations. Previous affiliations of Fiona E. Harrison include Allen Institute for Brain Science & Vanderbilt University.
Papers
More filters
Journal ArticleDOI
Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter (SVCT2)
Fiona E. Harrison,James M. May +1 more
TL;DR: Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic, and GABAergic transmission and related behaviors, posited to have potential therapeutic roles against ischemic stroke, Alzheimer's disease, Parkinson’s disease, and Huntington's disease.
Journal ArticleDOI
Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
TL;DR: Findings are important when considering the appropriate cognitive tasks for any experiment in which stress responses may differ systematically across groups, suggesting that performance on the water maze may be more affected by test-induced stress even within wild-type subjects of the same age and gender.
Journal ArticleDOI
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
TL;DR: Seven‐month‐old APPSwe’+ PSEN1ΔE9 mice were unimpaired on tests of memory that did not involve learning the rules governing spatial associations, and processes such as general rule learning, context learning and exploratory habituation exert a greater influence when the testing environment is novel.
Journal ArticleDOI
Role of vitamin C in the function of the vascular endothelium
James M. May,Fiona E. Harrison +1 more
TL;DR: A key focus for future studies of asCorbate and the vascular endothelium will likely be to determine the mechanisms and clinical relevance of ascorbate effects on endothelial function, permeability, and survival in diseases that cause endothelial dysfunction.
Journal ArticleDOI
Spatial and nonspatial escape strategies in the Barnes maze
TL;DR: It is concluded that the Barnes maze can be solved efficiently using spatial, visual cue, or serial-search strategies, however, mice showed a strong preference for using the distal room cues, even when a discrete visible cue clearly marked the escape location.