Showing papers by "Flaminia Pavone published in 1983"
TL;DR: Ethanol, at an ineffective dose, enhanced both the effects of morphine and those of immobilization stress, and the possibility that opiates may have a critical but modulatory effect on the actions of ethanol and/or immobilization is discussed.
Abstract: Performance impairments were evident, in CD1 mice tested in a passive avoidance apparatus, following posttrial intraperitoneal administration of ethanol (1.0 and 2.0 g/kg) or morphine (0.5 and 1.0 mg/kg), or following posttrial immobilization stress (30 and 60 min). Lower doses of ethanol (0.5 g/kg) or morphine (0.25 mg/kg), or a shorter immobilization time (15 min) were ineffective. Ethanol, at an ineffective dose (0.50 g/kg) enhanced both the effects of morphine and those of immobilization stress. The effects observed were antagonized by a per se ineffective dose of naloxone (1.0 mg/kg). The possibility that opiates may have a critical but modulatory effect on the actions of ethanol and/or immobilization is discussed.
16 citations
Journal Article•
TL;DR: In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity, and was most evident when caffeine was used in doses that slightly increased locomotor activity.
Abstract: In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same dose caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, and a direct action of caffeine on delta opiate receptors involved in the stimulatory effect of morphine.
6 citations