Showing papers by "Francesca Pelizzoni published in 1993"
TL;DR: This work reports on the reactions of the Reformatsky reagent tert-butoxycarbonylmethylzinc bromide with the acetylated glycals l-4, a stable, easily accessible, crystalline compound that can be easily transformed, and a CH,COOH substituent is “bioisosteric” with a phosphate group’.
13 citations
Patent•
16 Aug 1993
TL;DR: In this paper, combretastatin derivatives (I) with antitumoral activity and a process for the extraction and isolation thereof, from Combretum kraussii, were described.
Abstract: Herein disclosed are combretastatin derivatives (I) with antitumoral activity and a process for the extraction and isolation thereof, from Combretum kraussii; pharmaceutical compositions for antitumoral use and the preparation of said pharmaceutical compositions are also described, wherein R is H or CH3, R' is H or β-D-glucopyranose, and wherein A is a bivalent radical having two carbon atoms selected from -CH2-CH2- and -CH=CH-, provided that when R is CH3 R' is different from H.
7 citations
TL;DR: In this paper, a conformational analysis of (+)-spathulenol and its related stereoisomers was performed using the semi-empirical program mndo, and the obtained theoretical results were tested by checking the agreement of a selected calculated property (3 j H-H ) with the experimental value.
Abstract: A conformational analysis of (+)-spathulenol and its related stereoisomers was performed using the semiempirical program mndo . The obtained theoretical results were tested by checking the agreement of a selected calculated property ( 3 j H-H ) with the experimental value. The theoretical values of the vicinal coupling constants were calculated for all possible stereoisomers of spathulenol, including the ones not yet isolated, to allow their identification as natural and/or synthetic products. A biogenetic study was then undertaken using both the “saddle” technique, as implemented in the ampac package, and the coordinate reaction method. According to the results obtained, both spathulenol and allospathulenol should originate from two different conformations of a germacradiene precursor with both double bonds in the E configuration.
4 citations