Showing papers by "Francesco Boccardo published in 1989"
Journal Article•
133 citations
TL;DR: Twenty consecutive metastatic renal cell carcinoma patients were treated with a combination of recombinant α-2a interferon and vinblastine and found that most frequently, patients complained of fever and flu-like symptoms.
Abstract: Twenty consecutive metastatic renal cell carcinoma patients were treated with a combination of recombinant alpha-2a interferon (18 X 10(6) U three times weekly) and vinblastine (01 mg/kg every 3 weeks) Two patients (10% response rate; 95% confidence limits 123-317%) achieved partial response and 11 (55%) stable disease Toxicity was significant but always acceptable: most frequently, patients complained of fever and flu-like symptoms (18 of 19 patients), fatigue (18 of 19 patients), worsening in performance status (15 of 19 patients), and anorexia (15 of 19) The combination of recombinant alpha-2a interferon and vinblastine is active in renal cell carcinoma
17 citations
TL;DR: It is concluded that long-term treatment with luteinizing hormone-releasing hormone agonists in elderly men leads to gonadal impairment that may not be as reversible as generally suggested.
11 citations