F
Francesco De Nuccio
Researcher at University of Salento
Publications - 38
Citations - 1004
Francesco De Nuccio is an academic researcher from University of Salento. The author has contributed to research in topics: COPD & MPTP. The author has an hindex of 15, co-authored 33 publications receiving 785 citations.
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Journal ArticleDOI
A rapid and simple method for the determination of 3,4-dihydroxyphenylacetic acid, norepinephrine, dopamine, and serotonin in mouse brain homogenate by HPLC with fluorimetric detection.
Giuseppe E. De Benedetto,Daniela Fico,Antonio Pennetta,Cosimino Malitesta,Giuseppe Nicolardi,Dario Domenico Lofrumento,Francesco De Nuccio,Velia La Pesa +7 more
TL;DR: A fast and simple isocratic high-performance liquid chromatography method for the determination of 3,4-dihydroxyphenylacetic acid, dopamine, norepinephrine and serotonin in animal tissues employing the direct fluorescence of the neurotransmitters is described.
Journal ArticleDOI
Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson's-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses
Dario Domenico Lofrumento,Giuseppe Nicolardi,Antonia Cianciulli,Francesco De Nuccio,Velia La Pesa,Vito Emanuele Carofiglio,Teresa Dragone,Rosa Calvello,Maria Antonietta Panaro +8 more
TL;DR: Resveratrol treatment up-regulated the expression of the suppressor of cytokine signaling-1 (SOCS-1), supporting the hypothesis that resver atrol protects DA neurons of the SNpc against MPTP-induced cell loss by regulating inflammatory reactions, possibly through SOCS- 1 induction.
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Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson's Disease, Shifting M1 to M2 Microglia Responses.
Rosa Calvello,Antonia Cianciulli,Giuseppe Nicolardi,Francesco De Nuccio,Laura Giannotti,Rosaria Salvatore,Chiara Porro,Teresa Trotta,Maria Antonietta Panaro,Dario Domenico Lofrumento +9 more
TL;DR: It is demonstrated that vitamin D exhibits substantial neuroprotective effects in this PD animal model, by attenuating pro-inflammatory and up-regulating anti-inflammatory processes.
Journal ArticleDOI
MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain
Dario Domenico Lofrumento,Concetta Saponaro,Antonia Cianciulli,Francesco De Nuccio,Vincenzo Mitolo,Giuseppe Nicolardi,Maria Antonietta Panaro +6 more
TL;DR: Results indicate a role of both pro-inflammatory cytokines and their receptors in the pathogenesis of PD.
Journal ArticleDOI
A Krill Oil Supplemented Diet Suppresses Hepatic Steatosis in High-Fat Fed Rats
Alessandra Ferramosca,Annalea Conte,Lena Burri,Kjetil Berge,Francesco De Nuccio,Anna Maria Giudetti,Vincenzo Zara +6 more
TL;DR: The investigation of the molecular mechanisms of KO action in high-fat fed animals revealed a strong decrease in the activities of the mitochondrial citrate carrier and of the cytosolic acetyl-CoA carboxylase and fatty acid synthetase, which are both involved in hepatic de novo lipogenesis.