F
Francis Hsuan
Researcher at Temple University
Publications - 20
Citations - 525
Francis Hsuan is an academic researcher from Temple University. The author has contributed to research in topics: Bioequivalence & Population. The author has an hindex of 12, co-authored 20 publications receiving 503 citations.
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Journal ArticleDOI
A small sample confidence interval approach to assess individual bioequivalence.
TL;DR: An alternative confidence interval procedure to assess IBE by the FDA recommended criteria is developed, which utilizes Howe's approximation I to a Cornish-Fisher expansion, and can be easily programmed using readily available software.
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Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients
Miles G. Choc,Francis Hsuan,Gilbert Honigfeld,William T. Robinson,Larry Ereshefsky,Miles L. Crismon,Stephen R. Saklad,Jack Hirschowitz,Richard Wagner +8 more
TL;DR: The pharmacokinetic parameters between the initial and the final single dose periods were not significantly different and the terminal elimination rate differed between the single-dose and the multiple-dose treatments, but the dose-normalized area under the plasma concentration/time curves increased 27% with multiple dosing.
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Adaptive designs for dose-finding studies based on sigmoid Emax model.
TL;DR: An adaptive procedure for dose-finding in clinical trials when the primary efficacy endpoint is continuous is proposed, which model the mean of the efficacy endpoint, given the dose, as a four-parameter logistic function.
Journal ArticleDOI
Moment-based criteria for determining bioequivalence
Daniel J. Holder,Francis Hsuan +1 more
TL;DR: In this article, a moment-based criterion was proposed to insure interchangeability of formulations for at least a certain proportion of the population, and an algorithm was given for determining the constant in the criterion.
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The {2}-inverse with applications in statistics
TL;DR: In this article, the authors present a three-phase inversion procedure for generalized inverses, which is a special case of generalized inverse GAG = G. The geometry of {2}-inverses can be derived starting from generalized GAGs.