F
Francis Marsais
Researcher at Centre national de la recherche scientifique
Publications - 116
Citations - 2070
Francis Marsais is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Metalation & Deprotonation. The author has an hindex of 25, co-authored 116 publications receiving 1977 citations. Previous affiliations of Francis Marsais include Institut de Chimie des Substances Naturelles & University of Rouen.
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Journal ArticleDOI
New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines
Erwan Arzel,Patrick Rocca,Philippe Grellier,Mehdi Labaeid,François Frappier,Françoise Guéritte,Christiane Gaspard,Francis Marsais,Alain Godard,Guy Quéguiner +9 more
TL;DR: A new synthesis of benzo-δ-carbolines, cryptolepines, and their salts is described, based on the association between halogen-dance and hetero-ring cross-coupling, with interesting overall yields from 27% to 70%.
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Connection between metalation and cross-coupling strategies. A new convergent route to azacarbazoles.
P. Rocca,P. Rocca,Francis Marsais,Francis Marsais,A. Godard,A. Godard,Guy Quéguiner,Guy Quéguiner +7 more
TL;DR: New convergent synthesis of azacarbazoles through metalation, cross-coupling reaction and intramolecular substitution via (2-aminobenzene)boronic acid and ortho-fluoroiodopyridines as discussed by the authors.
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New Syntheses of Substituted Pyridines via Bromine–Magnesium Exchange
François Trécourt,Gilles Breton,Véronique Bonnet,Florence Mongin,Francis Marsais,Guy Quéguiner +5 more
TL;DR: Bromine-magnesium exchange using i PrMgCl in THF at room temperature on 2-, 3- and 4-bromopyridines allowed the synthesis of various functionalized pyridine.
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First metalation of aryl iodides: directed ortho-lithiation of iodopyridines, halogen-dance, and application to synthesis
P. Rocca,C. Cochennec,Francis Marsais,L. Thomas‐Dit‐Dumont,M. Mallet,Alain Godard,Guy Quéguiner +6 more
TL;DR: In this paper, the iodo group was used for metalation of iodopyridines at low temperature, and the resulting pyridine intermediates were obtained in high yields before being reacted with electrophiles leading to polyaromatic alkaloids.
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Recent advances in direct C–H arylation: Methodology, selectivity and mechanism in oxazole series
Cécile Verrier,Pierrik Lassalas,Laure Theveau,Guy Quéguiner,François Trécourt,Francis Marsais,Christophe Hoarau +6 more
TL;DR: Catalytic direct (hetero)arylation of (heterO)arenes is an attractive alternative to traditional Kumada, Stille, Negishi and Suzuki–Miyaura cross-coupling reactions, notably as it avoids the prior preparation and isolation of ( hetero)arylmetals.