1,8-Dihydroxy and 1,8-diacetoxy anthraquinones and derivatives thereof are used to treat the symptoms of arthritis.

Treatment of arthritis and substances for use in such treatment

The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.

Tetracyclic xanthene derivatives and methods of use thereof for the treatment of viral diseases

Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (adp-ribose) glycohydrolase, and methods for their use

Disclosed herein are antiviral agents, pharmaceutical formulations comprising effective amounts of these agents and methods for treating mammals suffering from infections caused by viruses. The agents are analogs, isomers, homologs, derivatives and salts of aromatic polycyclic diones.

Compositions and methods for treating viral infections

The present invention provides compounds of formula I wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl), -OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R2 is -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl),-OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-l-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; and n is 2 or 3; or a pharmaceutically acceptable salt or solvate thereof.

Benzofluorene compounds, intermediates, compositions, and methods

Disclosed are novel compounds and pharmaceutical formulations having antiviral activity. The disclosed compounds have the formula ##SPC1## Wherein one R 2 is a hydrogen atom and the other R 2 is the radical ##SPC2## A is a straight chain alkylene group having 2 or 3 carbon atoms and each R 3 and R 4 is a hydrogen atom, an alkyl radical having 1 to 3 carbon atoms or each set of R 3 and R 4 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group. Also included are the acid addition salts of these bases. These compounds may be prepared by various methods which are described.

Bis-basic ethers of 2,6,- and 2,7-dihydroxy-anthraquinones

Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1## Wherein Z is oxygen or H 2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##EQU1## wherein R 1 and R 2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R 3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##EQU3## wherein X is oxygen or NR 4 , and R 4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; Or a pharmaceutically acceptable acid addition salt thereof. These compounds can be prepared by several different methods.

Antiviral compositions containing bis-basic ketones of xanthene and xanthen-9-one

Novel 2,7-bis basic alkanol derivatives of xanthene and thioxanthene, their preparation and use for the prevention and inhibition of viral infections are disclosed.

Francis William Sweet

Papers

Bis-basic ethers of 2,6,- and 2,7-dihydroxy-anthraquinones

Antiviral compositions containing bis-basic ketones of xanthene and xanthen-9-one

Xanthene and thioxanthene derivatives