F
Frans ter Brake
Researcher at University of Groningen
Publications - 2
Citations - 110
Frans ter Brake is an academic researcher from University of Groningen. The author has contributed to research in topics: LRRK2 & Target protein. The author has an hindex of 2, co-authored 2 publications receiving 50 citations.
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Journal ArticleDOI
PROTACs- a game-changing technology.
Markella Konstantinidou,Jingyao Li,Bidong Zhang,Zefeng Wang,Shabnam Shaabani,Frans ter Brake,Khaled Essa,Alexander Dömling +7 more
TL;DR: PROTACs have shown remarkable biological responses in challenging targets, including an unprecedented selectivity over protein family members and even efficacy starting from weak or unspecific binders, and are expected to soon become a new therapeutic category of drugs.
Journal ArticleDOI
The tale of proteolysis targeting chimeras (PROTACs) for Leucine-Rich Repeat Kinase 2 (LRRK2).
Markella Konstantinidou,Asmaa Oun,Pragya Pathak,Bidong Zhang,Zefeng Wang,Frans ter Brake,Amalia M. Dolga,Arjan Kortholt,Arjan Kortholt,Alexander Dömling +9 more
TL;DR: The rational design and synthetic methodologies towards proteolysis‐targeting chimeras (PROTACs) for the recently‐emerged target leucine‐rich repeat kinase 2 (LRRK2) are presented.