Showing papers by "Franz Fazekas published in 1985"
TL;DR: In fourteen untreated migraine patients with a mean age of 40 years platelet sensitivity to 5HT, EN and ADP was investigated during the prodromal phase, 12-48 h after headache and during the headache-free period, and a varying sensibility of platelets to low concentrations of 5HT.
Abstract: In fourteen untreated migraine patients with a mean age of 40 years platelet sensitivity to 5HT, EN and ADP was investigated during the prodromal phase (three patients), 12-48 h after headache (three patients) and during the headache-free period (eight patients). Platelet sensitivity was tested using an optical density method and was calculated by the percentage of disaggregation (%DA) occurring 3 min after the peak aggregation. Platelet release reaction was assessed using beta-thromboglobulin (beta-TG) as an indicator. Platelet sensitivity to low concentrations of 5HT, EN and ADP (0.3 X 10(-9) M/ml) was most marked during the headache and prodromal phases. The least platelet sensitivity in migraineurs was detected during the headache-free interval, but was still higher than in the control group. beta-TG levels were increased during the headache phase indicating platelet release reaction. A general hyperaggregability of platelets in migraineurs has been demonstrated and in addition a varying sensibility of platelets to low concentrations of 5HT, EN and ADP has been established.
37 citations
01 Jan 1985
TL;DR: In this study CBF measurements have been performed in patients with idiopathic PD and the results compared with those obtained in Patients with PD and with evidence of cerebrovascular disease (CVD), arbitrarily termed “increased vascular risk” (IVR).
Abstract: It has been shown repeatedly that cerebral blood flow (CBF) measurements can be used to demonstrate functional changes in the brain. This is due to the fact that normally blood flow is controlled by the metabolism of the neuronal tissue. Measurements of CBF in Parkinson’s disease (PD) revealed a reduction of total as well as of regional CBF, but little attention has so far been paid to the underlying etiology as a possible cause of the CBF decline. In this study CBF measurements have been performed in patients with idiopathic PD and the results compared with those obtained in patients with PD and with evidence of cerebrovascular disease (CVD), arbitrarily termed “increased vascular risk” (IVR).
1 citations
01 Jan 1985
TL;DR: The results of CBF measurements in patients with epilepsy of different etiologies are described to describe the metabolic activity of the human brain under physiologic conditions.
Abstract: It is well accepted that measurements of cerebral blood flow (CBF) under physiologic conditions may reflect the metabolic activity of the human brain. Hence, in patients with epilepsy, CBF has been found to be increased during seizure attacks coinciding with an increased metabolic rate for oxygen and glucose. However, little information exists on whether CBF varies in patients with epilepsy of various etiologies. It is therefore the purpose of the present paper to describe the results of CBF measurements in patients with epilepsy of different etiologies.
1 citations