Showing papers by "Fred R. Hirsch published in 1994"
TL;DR: Twenty years ago, Pearse identified a group of endocrine cells sharing multiple morphological and biochemical features known as neuro-endocrine (NE) cells and the APUD system as the Dispersed Neuroendocrine System (DNS), currently consisting of more than 40 different cell types.
Abstract: Twenty years ago, Pearse identified a group of endocrine cells sharing multiple morphological and biochemical features. He named them APUD cells (Amine Precurser Uptake and Decarboxylation) because of their amine-handling properties, one of their main functions being their ability to take up and decarboxylate relatively simple amino precursor substances, such as dihydroxyphenylanaline (DOPA) and 5-hydroxytryptamine (5-HT), thus producing biogenic amines [1]. Today, these cells are known as neuro-endocrine (NE) cells and the APUD system as the Dispersed Neuroendocrine System (DNS), currently consisting of more than 40 different cell types.
5 citations
TL;DR: FucGM1 does not have a clinical role as a tumour marker for patients with SCLC at diagnosis or during treatment, and a correlation was found in 8 out of 20 patients as a monitor of clinical response.
2 citations