Fuchun Guo

TL;DR: The effects of combining shRNA targeting PKM2 and docetaxel on human A549 lung carcinoma cells both in vivo and in vitro suggest that targeting tumor glycolysis can increase the efficacy of chemotherapy.

TL;DR: This study provides the rationale for the clinical translation of CAR-modified T lymphocytes with VEGFR-1 specificity by electroporation and demonstrated the antitumor and anti-angiogenesis ability of V-1 CAR- modified T lymphocyte.

TL;DR: Gefitinib greatly enhanced NK cell cytotoxicity to lung cancer cells with EGFR L858R + T790M resistance mutation and combination of EGFR tyrokinase inhibitors and NK cells adoptive immunotherapy may represent a potentially effective strategy for patients with non-small cell lung cancer.

TL;DR: ThIORidazine was found to significantly inhibit breast tumor growth and the potential for thioridazine to be used in cancer therapy may be re-evaluated and investigated in clinical settings.

TL;DR: It is indicated that the FAP-modified whole-cell tumor vaccine induced strong antitumor immunity against both tumor cells and CAFs and reversed the immunosuppressive effects of tumors by decreasing the recruitment of immunOSuppressive cells and enhancing the recruitmentof effector T cells.