The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

Modulators of toll-like receptors

4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.

Therapeutic agents useful for treating pain

Disclosed is an adenine compound represented by the formula (I) below, which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. [In the formula, A represents a substituted or unsubstituted aromatic carbon ring or aromatic heterocyclic ring; L1 and L2 independently represent a single bond, a linear or branched alkylene group or the like; R1 represents a halogen atom or a substituted or unsubstituted alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aryl group or heteroaryl group; R2 and R3 independently represent a hydrogen atom or a substituted or unsubstituted alkyl group, alkenyl group, alkynyl group, cycloalkyl group, saturated heterocyclic group, aryl group or heteroaryl group, or alternatively R2 may combine with L2 or R3 to form a substituted or unsubstituted 4-8 membered nitrogen-containing saturated heterocyclic ring; and X represents an oxygen atom, a sulfur atom, SO, SO2, NR7, NR7CO (wherein R7 represents a hydrogen atom or an alkyl group) or a single bond. (In this connection, when R1 is a halogen atom, X is a single bond.)]

Novel adenine compound

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

Pyrimidine derivatives for the treatment of viral infections

Adenine derivatives represented by the following general formula (I) wherein X represents NR3 (wherein R3 represents hydrogen or C?1-3? alkyl), etc.; R?1? represents optionally substituted alkyl, etc.; R2 represents hydroxy, etc.; and Y represents an optionally substituted aromatic heterocycle, etc.; tautomers thereof or pharmaceutically acceptable salts thereof; and drugs such as interferon inducing agents, antiviral agents, anticancer agents, type 2 helper T cell-selective immune response inhibitors, antiallergic agents and immune response controlling agents containing the same as the active ingredient.

Novel adenine derivatives

A drug for topical administration which is effective as an antiallergic agent. The drug for topical administration contains as an active ingredient either an adenine compound represented by the general formula (1): (1) [wherein ring A represents a 6- to 10-membered, mono- or bicyclic, aromatic carbocycle or a 5- to 10-membered, mono- or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among zero to two nitrogen atoms, zero or one oxygen atom, and zero or one sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least either of Q1 and Q2 represents -COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

Fujita Hitoshi

Papers

Novel adenine compound and use thereof