G. Esposti

TL;DR: Evidence of the inhibitory effect of melatonin on beta-endorphin secretion and the stimulatory action of the opioid peptides on the pineal gland is provided, however, further studies will be required to clarify the relationship between the opioid system and the Pineal gland.

TL;DR: Results, by showing an apparent control of the neoplastic growth and an improvement in the quality of life in a reasonable number of cancer patients for whom no other standard therapy is available, would justify further clinical trials to better define the impact of MLT therapy on the survival andquality of life of untreatable advanced cancer patients.

TL;DR: Melatonin serum levels and its light/dark rhythm have been determined with the RIA method in patients affected by various forms of tumor, finding existence of two subpopulations within the oncologic patients, the former with normal levels of melatonin, and the latter with high ones.

TL;DR: The hypothesis that the opioidergic system, in certain circumstances, might contribute to the activation of melatonin secretion is supported.

TL;DR: To investigate the influence of pubertal development on the role of the pineal gland in the regulation of the secretion of pituitary hormones, FSH, LH, Prl, TSH and GH responses to melatonin were evaluated in a group of 9 prepubertal and 10 pubertAL healthy subjects of both sexes.