G
G. J. Zijlstra
Researcher at University Medical Center Groningen
Publications - 2
Citations - 154
G. J. Zijlstra is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Receptor & Glucocorticoid. The author has an hindex of 2, co-authored 2 publications receiving 133 citations.
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Journal ArticleDOI
Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells
G. J. Zijlstra,ten Nicolaas Hacken,Roland F. Hoffmann,A. J. M. Van Oosterhout,Irene H. Heijink +4 more
TL;DR: It is shown for the first time that IL-17A induces GC insensitivity in airway epithelium, which is probably mediated by PI3K activation and subsequent reduction of HDAC2 activity and may offer new strategies for therapeutic intervention in GC-insensitive asthma.
Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial
TL;DR: In this article, the authors investigated whether interleukin (IL)-17A induces glucocorticoid (GC) insensitivity in airway epithelium by studying its effects on responsiveness of tumour necrosis factor (TNF)-a-induced IL-8 production to budesonide in human bronchial epithelial 16HBE cells.