Devic’s disease, is also called neuromyelitis optica, it is a demyelinating autoimmune entity of the central nervous system, it is uncommon and it compromises the optic nerves and the spinal cord, causing loss of visual acuity and motor impairment. A clinical case of a 25-year-old woman with signs of sudden myelopathy and amaurosis is presented. It is fulfilling criteria for neuromyelitis optica. The treatment with methylprednisolone boluses started without any improvement, and Rituximab was applied with an early favorable response. Rituximab belongs to the group of anti-CD20 monoclonal antibodies, it was an important option in the absence of response to the first line of treatment.

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Enfermedad de Devic con respuesta favorable a rituximab: reporte de un caso

Article Info History Received: 09 July 2020 Accepted: 24 Nov 2020 Available: 31 Dec 2020 Abstract Background: Neuromyelitis Optica (NMO) is a rare autoimmune disease that covers 20-30% of diseases related to autoimmune disorders and about 1% of demyelination diseases. NMO symptoms are vary between individuals, there are generally 2 main symptoms, transverse myelitis and optic neuritis. It requires good knowledge and understanding of this disease so that proper management can be given as early as possible so as to reduce the morbidity and mortality of the disease. This article reported a child with NMO disease based on The Consensus of the International Panel for NMO Diagnosis (IPND) 2015. Case Presentation: An 8-year old boy with spastic tetra paresis, bilateral nervus opticus dysfunction, urinary retention, and allodyniaet causa suspected NMO. Patient received therapy using high-dose intravenous methylprednisolone and showing a clinical improvement. Conclusion: This patient was diagnosed NMO based on IPND 2015 with an unknown AQP4-Ab status accompanied by supporting clinical symptoms. The management of NMO with high-dose intravenous methylprednisolone in this patient provides a meaningful response to the clinical improvement of the disease.

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Neuromyelitis Optica (NMO) in Children: A Rare Case Report

There are a number of lesions which resemble tumors but are not neoplasms. Among these are the solitary bone cyst (simple or unicameral bone cyst), aneurysmal bone cyst, juxta-articular bone cyst (intraosseous ganglion), metaphyseal fibrous defect (nonossifying fibroma), eosinophilic granuloma, fibrous dysplasia, myositis ossificans, and the brown tumor of hyperparathyroidism.

G N Tewari

Papers

Devic's disease. A case report.