In this review, we have examined the biochemical and toxic responses produced by halogenated aromatic hydrocarbons and have tried to develop a model for their mechanism of action. These compounds bind to a cellular receptor and evoke a sustained pleiotropic response. In many tissues this response consists of the expression of a battery of enzymes which are, for the most part, involved in drug metabolism, but in other tissues, those which develop toxicity, an additional set of genes is expressed which effects cellular involution, division, and/or differentiation. The toxicity of these compounds appears to be due to the sustained expression of a normal cellular regulatory system, of which we were previously unaware. In future investigations it is hoped that we will learn the nature and physiologic role of this regulatory system. Only then can we hope to understand the mechanism of toxicity of these compounds.

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

Two-dimensionally extended, polycyclic heteroaromatic molecules (heterocyclic nanographenes) are a highly versatile class of organic materials, applicable as functional chromophores and organic semiconductors. In this Review, we discuss the rich chemistry of large heteroaromatics, focusing on their synthesis, electronic properties, and applications in materials science. This Review summarizes the historical development and current state of the art in this rapidly expanding field of research, which has become one of the key exploration areas of modern heterocyclic chemistry.

Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which contain these compounds.

Materials for organic electroluminescent devices

The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs.

The invention relates to the compounds of formulae (1) to (6) and to organic electroluminescent devices, especially blue-emitting devices, in which these compounds are used as the host material or doping agent in the emitting layer and/or as the hole transport material and/or as the electron transport material.

Novel Materials for Organic Electroluminescent Devices

Organs as targets of "dioxin" (2,3,7,8-tetrachlorodibenzo-p-dioxin) intoxication

Enzymatic functions as targets of the toxicity of "Dioxin" (2,3,7,8-tetrachlorodibenzo-p-dioxin).

504. Oxygen heterocycles. Part VIII. Aroylbenzofurans, aroyldibenzofurans, and aroylcoumarins of potential biological interest

The present invention relates to yohimbine derivatives. Said derivatives have the general formula ##SPC1## In which R is a radical ##EQU1## or R1 being an alkyl, aralkyl, alkylaryl, aryl group optionally carrying a nitro group, R2, R3 and R4 being hydrogen, a hydroxy, alkoxy or mono- or dialkylamino group. They possess hypotensive and cardio-stimulant properties.

G. Saint-Ruf

Papers

Organs as targets of "dioxin" (2,3,7,8-tetrachlorodibenzo-p-dioxin) intoxication

Enzymatic functions as targets of the toxicity of "Dioxin" (2,3,7,8-tetrachlorodibenzo-p-dioxin).

504. Oxygen heterocycles. Part VIII. Aroylbenzofurans, aroyldibenzofurans, and aroylcoumarins of potential biological interest

Yohimbine derivatives, process for their preparation and their applications

537. Further studies in the cyclodehydration of arylidene-α-tetralones