Showing papers by "Gareth A. Morris published in 2023"
TL;DR: An ultra-selective 1D NMR experiment, GEMSTONE-ROESY as mentioned in this paper , enables clear assignment of ROE signals in the not uncommon situation that traditional selective methods fail.
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TL;DR: In this paper , ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap.
TL;DR: In this paper , the benefits of combining pure shift methods with the CASPER computational approach to resonance assignment in oligosaccharides are demonstrated, which can greatly reduce the signal overlap in 1H spectra.
Abstract: Human milk oligosaccharides belong to an important class of bioactive molecules with diverse effects on the development of infants. NMR is capable of providing vital structural information about oligosaccharides which can aid in determining structure-function relationships. However, this information is often concealed by signal overlap in 1H spectra, due to the narrow chemical shift range and signal multiplicity. Signal overlap in oligosaccharide spectra can be greatly reduced, and resolution improved, by utilising pure shift methods. Here the benefits of combining pure shift methods with the CASPER computational approach to resonance assignment in oligosaccharides are demonstrated.