Showing papers by "Gaurav Sharma published in 1982"

Clinical Use of Thrombolytic Agents in Venous Thromboembolism

Abstract: • The use of thrombolytic agents in venous thromboembolism has been shown to be highly effective. Patients treated with lytic agents show more rapid clot resolution and lung reperfusion and more rapid and greater reversal of the abnormal hemodynamic responses to pulmonary embolism than patients receiving heparin. Moreover, lytic therapy removes thromboemboli more completely from the pulmonary microcirculation, whereas residual thromboemboli tend to accumulate with heparin therapy. In addition, lytic therapy tends to preserve the venous valves, whereas distortion and destruction occur with heparin therapy. Hence, lytic therapy confers a number of short- and long-term benefits not observed with heparin therapy. ( Arch Intern Med 1982;142:684-688)

Pulmonary embolism, pulmonary microcirculation, and thrombolytic therapy.

Abstract: For over 30 years, the mainstay of the acute treatment of venous thromboembolism has been heparin therapy. Because it performed its task so well and has withstood the test of time, many have considered its use definitive. Heparin’s action, however, is only preventive. It stops enlargement and propagation of thrombi and, in doing so, prevents recurrent pulmonary embolism. It does not, however, have any direct action upon thromboemboli in the circulation. The therapeutic need, then, was for the development of an