G
Gavin E. Morris
Researcher at University of Nottingham
Publications - 20
Citations - 730
Gavin E. Morris is an academic researcher from University of Nottingham. The author has contributed to research in topics: Vascular smooth muscle & G protein-coupled receptor kinase. The author has an hindex of 16, co-authored 18 publications receiving 650 citations. Previous affiliations of Gavin E. Morris include University of Leicester & University of Sydney.
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Journal ArticleDOI
Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides
James E. Dixon,Gizem Osman,Gavin E. Morris,Hareklea Markides,Michael Rotherham,Zahia Bayoussef,Alicia J. El Haj,Chris Denning,Kevin M. Shakesheff +8 more
TL;DR: A peptide-based system engineered to enhance the activity of cell-penetrating peptides to achieve exceptional intracellular transduction and represents an efficient strategy for controlling cell labeling and directing cell fate or behavior that has broad applicability for basic research, disease modeling, and clinical application.
Journal ArticleDOI
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.
TL;DR: Data indicate that potent amplification of inflammation induced by TLR agonists, such as LPS, may be achieved by cooperativity between airway smooth muscle and leukocytes involved in immune surveillance or inflammation.
Journal ArticleDOI
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
Gavin E. Morris,Lisa C. Parker,Jon R. Ward,Elizabeth C. Jones,Moira K. B. Whyte,Christopher E. Brightling,Peter Bradding,Steven K. Dower,Ian Sabroe +8 more
TL;DR: Inflammatory responses to pathogens are regulated by networks in which patterns of TLR expression and colocalization of tissue cells and leukocytes are critical, and the roles of such networks in response to agonists of TLRs associated with antiviral and autoimmune responses are determined.
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Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2
Gavin E. Morris,Carl P. Nelson,Nicholas B. Standen,R. A. John Challiss,Jonathon M. Willets,Jonathon M. Willets +5 more
TL;DR: These studies identify GRK2 as a key regulator of ETAR responsiveness in resistance arteries, highlighting the potential importance of this GRK isoenzyme in regulating vasoconstrictor signalling pathways implicated in vascular disease.
Journal ArticleDOI
A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing.
Catherine M Rogers,Gavin E. Morris,Toby W.A. Gould,Robert Bail,Sotiria Toumpaniari,Helen Harrington,James E. Dixon,Kevin M. Shakesheff,Joel Segal,Felicity R. A. J. Rose +9 more
TL;DR: A novel, versatile and scalable method to produce hybrid electrospun scaffolds consisting of both random fibres and a defined three-dimensional micro-topography at the surface is investigated, using patterned resin formers produced by rapid prototyping (RP).