Phloroglucinol compounds of natural origin

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The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structure and bioactivity diversity. This review discusses the progress of research into the chemistry and biological activity of 421 natural PPAPs in the past 11 years as well as in-depth studies of biological activities and total synthesis of some PPAPs isolated before 2006. We created an online database of all PPAPs known to date at http://www.chem.uky.edu/research/grossman/PPAPs. Two subclasses of biosynthetically related metabolites, spirocyclic PPAPs with octahydrospiro[cyclohexan-1,5′-indene]-2,4,6-trione core and complicated PPAPs produced by intramolecular [4 + 2] cycloadditions of MPAPs, are brought into the PPAP family. Some PPAPs’ relative or absolute configurations are reassigned or critically discussed, and the confusing trivial names in PPAPs investigations are clarified. Pharmacologic stu...

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols.

Propolis research and the chemistry of plant products

Structural diversity and bioactivities of natural benzophenones.

Prenylated benzophenone derivatives from Caribbean Clusia species (Guttiferae). Plukenetiones B-G and xerophenone A

Plukenetione A. An unusual adamantyl ketone from Clusia plukenetii (guttiferae)

Extracts of the fruit of Clusia havetiodes var. stenocarpa have yielded three new prenylated benzophenone derivatives, 28,29-epoxyplukenetione A (1), 33-hydroperoxyisoplukenetione C (2), and 15,16-dihydro-16-hydroperoxyplukenetione F (3), as well as four which have been previously described, plukenetiones C, F, and G and sampsonione G.

Geneive E Henry

Papers

Prenylated benzophenone derivatives from Caribbean Clusia species (Guttiferae). Plukenetiones B-G and xerophenone A

Plukenetione A. An unusual adamantyl ketone from Clusia plukenetii (guttiferae)

Prenylated benzophenone derivatives from Clusia havetiodes var. stenocarpa.

A short synthesis of 5-methoxy-2,2-dimethyl-2 H -1-benzopyran-6-propanoic acid methyl ester

Xerophenones A and B. New isoprenylated derivatives of 11-oxatricyclo[4.3.1.14,10]undecane-7,9-dione from Clusia portlandiana (Guttiferae)