Showing papers by "George Paxinos published in 1981"
TL;DR: The existence of a neuronal pathway containing Leu-enkephalin and connecting the neostriatum with the globus pallidus has been confirmed combining immunohistochemistry with microinjections of neurotoxic agents and discrete knife lesions.
Abstract: The existence of a neuronal pathway containing Leu-enkephalin and connecting the neostriatum with the globus pallidus has been confirmed combining immunohistochemistry with microinjections of neurotoxic agents (kainic acid, colchicine) and discrete knife lesions. The presence of substance P in nerve terminals of the substantia nigra was demonstrated by the application of a monoclonal antibody against this peptide. Electron microscopic studies revealed immunoreactive sites for substance P in nerve terminals establishing symmetric and asymmetric synapses, mainly over dendritic profiles. The possible peptide-containing neuronal pathways in the nigro-striatal system are discussed.
36 citations
TL;DR: It is suggested that both 5-HT and the catecholamines play a role in PCA-induced hypothermia, ejaculation, and salivation, and irritability in male rats.
Abstract: Injections of p-chloroamphetamine (PCA, 5 mg/kg) induced hypothermia, ejaculation, salivation and irritability in male rats kept at an ambient temperature of 20±1°C. PCA-induced hypothermia was attenuated by pretreatment with the 5-hydroxytryptamine (5-HT) uptake blockers Lundbeck 10–171 (Lu 10–171, 10 mg/kg) and chlorimipramine (CMI, 20 mg/kg) and the 5-HT synthesis inhibitor parachlorophenylalanine (PCPA, 150 mg/kg daily for 3 days); it was potentiated by pretreatment with the noradrenaline uptake blocker Lundbeck 5-003 (Lu 5-003, 10 mg/kg) and the catecholamine synthesis inhibitor alpha-methyl-p-tyrosine (AMPT, 50 mg/kg every 3 hr for 9 hr). PCA-induced ejaculation was attenuated by pretreatment with Lu 10–171 and CMI. PCA-induced salivation was attenuated by pretreatment with Lu 10–171 and CMI and potentiated by pretreatment with Lu 5-003. PCA-induced irritability was potentiated by pretreatment with PCPA. These results suggest that both 5-HT and the catecholamines play a role in PCA-induced hypothermia, ejaculation, and salivation.
28 citations
TL;DR: It was concluded that hypothalamic epinephrine was central in origin and not related to adrenal demedullation or surgical hemisection of ascending projections to the hypothalamus.
10 citations
01 Jan 1981
TL;DR: Membrane-bound enkephalinase and aminopeptidase activities have been measured in forty regions of rat brain and corresponding activity corresponds with reported enkphalin distributions whereas aminopedidase does not.
Abstract: Membrane-bound enkephalinase and aminopeptidase activities have been measured in forty regions of rat brain. Enkephalinase activity corresponds with reported enkephalin distributions whereas aminopeptidase does not.
1 citations