G
Gerald Moncayo
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 13
Citations - 567
Gerald Moncayo is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Glioma & Signal transduction. The author has an hindex of 10, co-authored 13 publications receiving 507 citations. Previous affiliations of Gerald Moncayo include University of Natural Resources and Life Sciences, Vienna & University of Oxford.
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Journal ArticleDOI
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma
Michal Grzmil,Pier Jr Morin,Maria Maddalena Lino,Adrian Merlo,Stephan Frank,Yuhua Wang,Gerald Moncayo,Brian A. Hemmings +7 more
TL;DR: Findings offer insights into how MNK1 pathways control translation of cancer-related mRNAs including SMAD2, a key component of the TGF-β signaling pathway, and suggestMNK1-controlled translational pathways in targeted strategies to more effectively treat GBM.
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Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme
Yuhua Wang,Gerald Moncayo,Pier Jr Morin,Pier Jr Morin,Gongda Xue,Michal Grzmil,M M Lino,V Clément-Schatlo,Stephan Frank,Adrian Merlo,Brian A. Hemmings +10 more
TL;DR: The show that the receptor tyrosine kinase Mer (MerTK) is overexpressed in glioblastoma multiforme (GBM) and that this is accompanied with increased invasive potential suggests that MerTK is a novel therapeutic target in the treatment of the malignant gliomas.
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MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas
Michal Grzmil,Roland M. Huber,Daniel Hess,Stephan Frank,Debby Hynx,Gerald Moncayo,Dominique Klein,Adrian Merlo,Brian A. Hemmings +8 more
TL;DR: Combined MNK1 and mTORC1 inhibition profoundly inhibited 4EBP1 phosphorylation at Ser65, protein synthesis and proliferation in glioma cells, and reduced tumor growth in an orthotopic glioblastoma (GBM) mouse model, indicating a molecular cross-talk between the m TORC1 andMNK1 pathways that has potential to be exploited therapeutically.
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The platelet receptor CLEC-2 is active as a dimer
Aleksandra A. Watson,Charita M. Christou,John R. James,Angharad E. Fenton-May,Gerald Moncayo,Anita R. Mistry,Simon J. Davis,Robert J.C. Gilbert,Aron Chakera,Christopher A. O’Callaghan +9 more
TL;DR: CLEC-2 exists as a non-disulfide-linked homodimer which could allow each Syk molecule to interact with two YXXL motifs, one from each CLEC- 2 monomer.
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A functional chimaeric S-layer-enhanced green fluorescent protein to follow the uptake of S-layer-coated liposomes into eukaryotic cells.
Nicola Ilk,Seta Küpcü,Gerald Moncayo,Sigrid Klimt,Rupert C. Ecker,Renate Hofer-Warbinek,Eva M. Egelseer,Uwe B. Sleytr,Margit Sára +8 more
TL;DR: The chimaeric gene encoding a C-terminally truncated form of the S-layer protein SbpA of Bacillus sphaericus and the EGFP was ligated into plasmid pET28a and cloned and expressed in Escherichia coli, showing the ability to self-assemble in suspension and to recrystallize on peptidoglycan-containing sacculi or on positively charged liposomes, as well as to fluoresce.