G
Gernot Seebacher
Researcher at Medical University of Vienna
Publications - 54
Citations - 3113
Gernot Seebacher is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Transplantation & Lung transplantation. The author has an hindex of 26, co-authored 53 publications receiving 2926 citations. Previous affiliations of Gernot Seebacher include University of Vienna.
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Journal ArticleDOI
Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients.
Paul Simon,Marie-Theres Kasimir,Gernot Seebacher,G. Weigel,Robert Ullrich,U. Salzer-Muhar,Erwin Rieder,Ernst Wolner +7 more
TL;DR: The xenogenic collagen matrix of the Synergraft valve elicits a strong inflammatory response in humans which is non-specific early on and is followed by a lymphocyte response, which may indicate manufacturing problems.
Journal ArticleDOI
Decellularization protocols of porcine heart valves differ importantly in efficiency of cell removal and susceptibility of the matrix to recellularization with human vascular cells
Erwin Rieder,Marie-Theres Kasimir,Gerd R. Silberhumer,Gernot Seebacher,Ernst Wolner,Paul Simon,Guenter Weigel +6 more
TL;DR: Only the porcine matrix treated with a new detergent-based decellularization method using 0.25% tert-octylphenyl-polyoxyethylen/sodium-deoxycholate followed by nuclease digestion presented an excellent scaffold for recellularization with human cells.
Journal ArticleDOI
Comparison of different decellularization procedures of porcine heart valves
Marie-Theres Kasimir,Erwin Rieder,Gernot Seebacher,Gerd R. Silberhumer,Ernst Wolner,G. Weigel,Paul Simon +6 more
TL;DR: Techniques of decellularization are highly variable in efficiency and matrix preservation and was best achieved in this study with Triton-X100® and sodium deoxycholate.
Journal ArticleDOI
Tissue Engineering of Heart Valves: Decellularized Porcine and Human Valve Scaffolds Differ Importantly in Residual Potential to Attract Monocytic Cells
Erwin Rieder,Gernot Seebacher,Marie-Theres Kasimir,Eva Eichmair,Birgitta Winter,Barbara Dekan,Ernst Wolner,Paul Simon,Guenter Weigel +8 more
TL;DR: It is described for the first time that the remaining potential of decellularized pulmonary heart valves to attract monocytic cells depends strongly on whether porcine or human scaffolds were used.
Journal Article
Decellularization does not eliminate thrombogenicity and inflammatory stimulation in tissue-engineered porcine heart valves.
Marie-Theres Kasimir,Erwin Rieder,Gernot Seebacher,Anneliese Nigisch,Barbara Dekan,Ernst Wolner,Guenter Weigel,Paul Simon +7 more
TL;DR: The decellularized porcine heart valve matrix has the potential to attract inflammatory cells and to induce platelet activation and the findings suggest that it will be important to control the different inflammation-stimulating factors if porcines tissues are to be used successfully in tissue engineering.