GianLuca Colussi

TL;DR: Primary aldosteronism is associated with a cardiovascular complication rate out of proportion to blood pressure levels that benefits substantially from surgical and medical treatment in the long term.

TL;DR: In the majority of patients in this study, primary aldosteronism was characterized by partially reversible renal dysfunction in which elevated albuminuria is a marker of a dynamic rather than structural renal defect.

TL;DR: In the long-term, both adrenalectomy and spironolactone are effective in reducing left ventricular mass in patients with primary aldosteronism, with effects that are partially independent of blood pressure changes.

TL;DR: Insulin resistance is present in patients with tumoral and idiopathic aldosteronism, but the defect appears less severe than in patientsWith essential hypertension, treatment with surgery or aldosterone antagonists restores rapidly and persistently normal sensitivity to insulin.

TL;DR: In this paper, the insulin receptor binding characteristics were determined by an in situ autoradiographic technique associated with computerized microdensitometry, which indicated decreased number of insulin receptors occurring at the level of gene expression is present in skeletal muscle and liver of fructose-fed rats and might contribute to insulin resistance in this model.