G
Gillian Murphy
Researcher at Royal Melbourne Hospital
Publications - 1
Citations - 292
Gillian Murphy is an academic researcher from Royal Melbourne Hospital. The author has contributed to research in topics: Cleavage (embryo) & Aggrecan. The author has an hindex of 1, co-authored 1 publications receiving 288 citations.
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The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
TL;DR: Investigation on aggrecan the major proteoglycan of cartilage shows that in spite of a high keratan sulfate content the interglobular domain provides important sites for cleavage by different proteinases, including several members of the matrix metalloproteinase family.