Giorgia Dina

TL;DR: In this article, adult neural stem cells were transplanted into mice to promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis.

TL;DR: It is found that mitochondrial morphological abnormalities occurred in synaptic terminals and in distal regions of axons long before the first signs of swelling and degeneration and correlated with onset of motor impairment during a rotarod test.

TL;DR: It is shown that GFAP and the other Schwann-cell-intermediate filament vimentin physically interact in two distinct signaling pathways involved in proliferation and nerve regeneration, which might contribute to form macro-complexes to initiate mitogenic and differentiating signaling for efficient nerve regeneration.

TL;DR: It is proposed that Schwann cell–autonomous loss of Mtmr2–Dlg1 interaction dysregulates membrane homeostasis in the paranodal region, thereby producing outfolding and recurrent loops of myelin.

TL;DR: The onset of myelination in nerve and synchronized myelinating cultures to the appearance of integrins and dystroglycan in Schwann cells suggests that the action of laminin is mediated by β1 Integrins during axonal sorting and by dysteglycan, α6 β1, and α6β4 integrin during myelinations.