Giovanni B. Brandani

TL;DR: Analysis of the trajectories via Markov state modeling highlights how the sequence-dependence of the sliding dynamics is due to the different twist defect energy costs, and in particular how nucleosome regions where defects cannot easily form introduce the kinetic bottlenecks slowing down repositioning.

TL;DR: In this paper, it was shown that the amino acids making up the surface-exposed hydrophobic cap in the crystal structure are shielded in aqueous solution by adopting a random coil conformation, enabling the protein to be soluble and monomeric.

TL;DR: This work investigated thermally-activated spontaneous nucleosome sliding mechanisms developing and applying a coarse-grained molecular simulation method that incorporates both long-range electrostatic and short-range hydrogen-bond interactions between histone octamer and DNA, revealing two distinct sliding modes depending on the nucleosomal DNA sequence.

TL;DR: The molecular mechanism of active nucleosome sliding is investigated by means of molecular dynamics simulations of the Snf2 remodeler translocase in complex with a nucleosomes to offer a detailed mechanistic picture of remodeling important for the complete understanding of these key biological processes.

TL;DR: In this article, the authors present a method to quantify the extent of disorder in a system by using conditional entropies, and apply it to mixing and demixing in multicomponent fluid membranes.