Showing papers by "Giulia Pasello published in 2012"
Journal Article•
TL;DR: AC and AP are active and feasible neoadjuvant regimens for malignant pleural mesothelioma and the lower tolerability to AP treatment could impair the clinical condition of patients undergoing surgery.
Abstract: Aim: The objective of this study was the retrospective evaluation of tolerability and activity of pemetrexed with carboplatin (AC) or cisplatin (AP) as neoadjuvant chemotherapy in a consecutive series of patients with malignant pleural mesothelioma (MPM). Patients and Methods: Patients with operable MPM received three cycles of AC or AP followed by surgery and radiotherapy. Results: Since 2005, 51 patients have been treated with AC (27) and AP (24). We observed higher incidence of grade 3 anaemia, cumulative grade 2-3 asthenia and worsening of performance status in the AP group. Response to AC and AP were; complete: 4% vs. 0%, partial: 18% vs. 17%, stable disease: 74% vs. 79%, progressive disease: 4%; the resection rate was 81% vs. 79%. Conclusion: AC and AP are active and feasible neoadjuvant regimens. Progression-free survival, response, disease control and resection rate were similar in the two treatment groups. The lower tolerability to AP treatment could impair the clinical condition of patients undergoing surgery.
5 citations
19 Dec 2012
TL;DR: Despite the extraction, import and marketing of the mineral were banned in most of the industrialized nations, the epidemiologic data foresee a sharp rise of MPM incidence and mortality in the next fifteen years because of the long lag time from exposure to clinical evidence.
Abstract: Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with a poor prognosis, directly related to chronic inhalation of asbestos fibres. Despite the extraction, import and marketing of the mineral were banned in most of the industrialized nations, the epidemiologic data foresee a sharp rise of MPM incidence and mortality in the next fifteen years because of the long lag time (even 40 years) from exposure to clinical evidence (Marinaccio et al., 2007).
4 citations
TL;DR: A retrospective survey on elderly patients with malignant pleural mesothelioma in four Oncology Departments with high MPM accrual and expertise found 210 elderly pts with MPM were identified, accounting for 34% of the whole MPM population observed in the study period.
Abstract: 7082 Background: The incidence of malignant pleural mesothelioma (MPM) in elderly patients (pts) is increasing in Western countries. Elderly pts with MPM are under-represented in clinical trials, a...
1 citations