G
Giuseppe De Gregorio
Researcher at University of Milan
Publications - 1
Citations - 113
Giuseppe De Gregorio is an academic researcher from University of Milan. The author has contributed to research in topics: Homologous recombination & Non-homologous end joining. The author has an hindex of 1, co-authored 1 publications receiving 99 citations.
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Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.
Matteo Ferrari,Diego Dibitetto,Giuseppe De Gregorio,Vinay V. Eapen,Chetan C. Rawal,Federico Lazzaro,Michael Tsabar,Federica Marini,James E. Haber,Achille Pellicioli +9 more
TL;DR: Deletion of the yeast 53BP1-ortholog RAD9 reduces Mre11 binding to a DSB, leading to Rad52 recruitment and efficient DSB end-tethering, through an Sgs1-dependent mechanism, and restores DSB repair either in absence of Sae2 or in presence of a nuclease defective MRX complex.