Showing papers by "Giuseppe G. Pietra published in 1988"
TL;DR: Neither the severity of the emphysema nor the time course of its development was altered by the beta APN-supplemented diet, and it is suggested that elastin synthesis and repair may not modulateElastin destruction in the NO2 model of emphySEma.
Abstract: We evaluated the effect of beta-aminopropionitrile (βAPN) on the nitrogen dioxide (NO2) animal model of emphysema. Rats maintained on a βAPN-supplemented or a regular diet were exposed to 30 ppm NO2 for intervals ranging from 1 to 8 wk. Emphysema development was assessed by histologic evaluation and by changes in lung volume and mean linear intercept values. Evidence of pathologic changes were also documented by clinical and radiographic findings of osteolathyrism. The induction of centriacinar emphysema was attributed specifically to NO2 exposure. Neither the severity of the emphysema nor the time course of its development was altered by the βAPN-supplemented diet. These findings are in marked contrast to those observed with the exogenous elastase model of the disease, and they suggest that elastin synthesis and repair may not modulate elastin destruction in the NO2 model of emphysema.
14 citations
Journal Article•
TL;DR: It is found that hypertonic solutions, dextran sulfate, and chloroquine inhibit cationized ferritin accumulation in multivesicular bodies and in the extravascular space, suggesting a general role of the endothelial acidic compartments in modulating microvascular permeability to macromolecules.
6 citations
01 Jan 1988
2 citations