Giuseppe Palermo

TL;DR: The R package crmPack provides a simple and unified object-oriented framework for model-based dose escalation designs that enables the standard use of such designs, while being able to flexibly adapt and extend them.

TL;DR: Inositol polyphosphate-5-phosphatase F (INPP5F) is identified as a prognostic factor for progression-free survival and overall survival and may serve as a novel, easy-to-assess future prognostic biomarker for fludarabine-based therapy in CLL.

TL;DR: Strong evidence of test-retest reliability, known-groups validity and ability to detect change was demonstrated and cUHDRS is valid, reliable and able to detects change in patients with early manifest HD.

TL;DR: This first‐in‐human study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, and maximum tolerated dose (MTD) of single ascending oral doses of RG7342, a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5) for the treatment of schizophrenia, in healthy male subjects.

TL;DR: In this paper, a random forest regression model was trained to predict change of clinical outcomes based on the variables, which were ranked based on their contribution to the prediction, and the highest-ranked variables included novel predictors of progression, being accompanied at clinical visit, cognitive impairment, age at diagnosis and tetrabenazine or antipsychotics use.