G
Glen K. Andrews
Researcher at University of Kansas
Publications - 130
Citations - 11642
Glen K. Andrews is an academic researcher from University of Kansas. The author has contributed to research in topics: Gene expression & Zinc. The author has an hindex of 60, co-authored 130 publications receiving 11213 citations. Previous affiliations of Glen K. Andrews include Cornell University.
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Regulation of metallothionein gene expression by oxidative stress and metal ions
TL;DR: The studies suggest that the DNA-binding activity of MTF-1 in vivo and in vitro is reversibly activated by zinc interactions with the zinc-finger domain, reflecting heterogeneity in the structure and function of the six zinc fingers.
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Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation
Sanjoy K. Das,Xiao-Ning Wang,Bibhash C. Paria,D. Damm,J. A. Abraham,Michael Klagsbrun,Glen K. Andrews,Sudhansu K. Dey +7 more
TL;DR: Possible interactions between the uterine HB-EGF and blastocyst EGF-R very early in the process of implantation, earlier than any other embryo-uterine interactions defined to date at the molecular level are suggested.
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The Transcription Factor MTF-1 Mediates Metal Regulation of the Mouse ZnT1 Gene
TL;DR: Results suggest that MTF-1 mediates the response to metal ions of both the ZnT1 and the MT-I genes the visceral yolk sac, and directly coordinates the regulation of genes involved in zinc homeostasis and protection against metal toxicity.
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Cellular zinc sensors: MTF-1 regulation of gene expression
TL;DR: The current model suggests that the zinc-finger domain of MTF-1 directly (and reversibly) binds to zinc, and this metalloregulatory protein then adopts a DNA-binding conformation and translocates to the nucleus, where it binds to metal-response elements in these gene promoters leading to increased transcription.
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Estrogen Regulates the Synthesis of Epidermal Growth Factor in Mouse Uterine Epithelial Cells
Yvette M. Huet-Hudson,Chandan Chakraborty,Swapan K. De,Yasunobu Suzuki,Glen K. Andrews,Sudhansu K. Dey +5 more
TL;DR: Results suggest that estrogen regulates expression of the EGF gene specifically in uterine epithelial cells, which results in an increase in the relative rate of synthesis of this protein and the accumulation of mature EGF.