G
Gnanasambandam Kumaravel
Researcher at Biogen Idec
Publications - 49
Citations - 1165
Gnanasambandam Kumaravel is an academic researcher from Biogen Idec. The author has contributed to research in topics: Adenosine receptor & Autotaxin. The author has an hindex of 19, co-authored 49 publications receiving 1117 citations. Previous affiliations of Gnanasambandam Kumaravel include Millennium Pharmaceuticals & Sunesis Pharmaceuticals.
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Journal ArticleDOI
Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions
Bing Yan,Gnanasambandam Kumaravel,Harshad Anjaria,Aiyin Wu,Petter Russell C,Charles F. Jewell,James R. Wareing +6 more
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Progression of Organic Reactions on Resin Supports Monitored by Single Bead FTIR Microspectroscopy.
TL;DR: The results showed that solid-phase organic reactions proceed faster than generally speculated, and the capability of obtaining IR spectra from the partial surface of a single bead demonstrated the femtomolar detection limit of single bead FTIR microspectroscopy.
Journal ArticleDOI
Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.
Chi Vu,Pamela Shields,Bo Peng,Gnanasambandam Kumaravel,Xiaowei Jin,Deepali Phadke,Joy Wang,Thomas Engber,Eman Ayyub,Petter Russell C +9 more
TL;DR: It is demonstrated that potent and selective A(2a) receptor antagonists could still be obtained when the arylpiperazines are separated from the triazolotriazine core structure by an ethylenediamine spacer.
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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Daniel A. Erlanson,Joseph Arndt,Mark T. Cancilla,Kathy Cao,Robert A. Elling,Nicki English,Jessica E. Friedman,Stig Hansen,C Hession,Ingrid Joseph,Gnanasambandam Kumaravel,Wen-Cherng Lee,Ken E. Lind,Robert S. McDowell,Konrad Miatkowski,Christine Nguyen,Thinh Ba Nguyen,Sophia Park,Nuzhat Pathan,David M. Penny,Michael J. Romanowski,Daniel Scott,Laura Silvian,Robert Lowell Simmons,Bradley T. Tangonan,Wenjin Yang,Lihong Sun +26 more
TL;DR: A fragment-based lead discovery method, Tethering with extenders, is used to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1, which binds in the 'DFG-out' conformation.
Journal ArticleDOI
Novel Diamino Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists
Chi Vu,Deborah Pan,Bo Peng,Gnanasambandam Kumaravel,Glenn Smits,Xiaowei Jin,Deepali Phadke,Thomas Engber,Carol Huang,Jennifer Reilly,Stacy Tam,Donna Grant,Gregg Hetu,Petter Russell C +13 more
TL;DR: Select analogues from this series of [1,2,4]triazolo[1,5-a][1,3,5]triazine have now been shown to be orally active in the mouse catalepsy model.