G
Gonzalo Mazzei
Publications - 3
Citations - 823
Gonzalo Mazzei is an academic researcher. The author has contributed to research in topics: CD40 & CCL5. The author has an hindex of 3, co-authored 3 publications receiving 811 citations.
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Induction of human IgE synthesis in B cells by mast cells and basophils
Jean François Gauchat,Sybille Henchoz,Gonzalo Mazzei,Jean Pierre Aubry,Thomas Brunner,Horst Blasey,Paul Life,Dominique Talabot,Leopoldo Flores-Romo,Jeffrey C. Thompson,Kenji Kishi,Joseph H. Butterfield,Clemens A. Dahinden,Jean Yves Bonnefoy +13 more
TL;DR: It is reported that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis, suggesting that mast cells and Basophils may play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells.
Journal ArticleDOI
CD40 ligand is functionally expressed on human eosinophils.
Jean-François Gauchat,Sybille Henchoz,Dilnya Fattah,Gonzalo Mazzei,Jean-Pierre Aubry,Therese Jomotte,Laura Dash,Kevin Page,Roberto Solari,Delphine Aldebert,Monique Capron,Clemens A. Dahinden,Jean-Yves Bonnefoy +12 more
TL;DR: Eosinophils were able to induce, in conjunction with IL‐4, CD40L‐dependent B cell proliferation in vitro, and these results suggest thatCD40L could play a role in the inflammatory processes during which eos inophil infiltration and activation are observed.
Journal ArticleDOI
Monoclonal antibodies reacting with the interleukin 1 receptor define a multi-molecular complex.
TL;DR: These are the first anti‐mouse IL 1R antibodies to be described which clearly and profoundly affect the immune response and clearly interfere with IL 1 responses both in vitro and in vivo.