G
Götz Schlotterbeck
Researcher at Hoffmann-La Roche
Publications - 37
Citations - 2674
Götz Schlotterbeck is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Proton NMR. The author has an hindex of 22, co-authored 31 publications receiving 2360 citations. Previous affiliations of Götz Schlotterbeck include University of Tübingen.
Papers
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Journal ArticleDOI
Probabilistic Quotient Normalization as Robust Method to Account for Dilution of Complex Biological Mixtures. Application in 1H NMR Metabonomics
TL;DR: The probabilistic quotient normalization is introduced in this work, which is based on the calculation of a most probable dilution factor by looking at the distribution of the quotients of the amplitudes of a test spectrum by those of a reference spectrum.
Journal ArticleDOI
Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia
Daniela Alberati,Jean-Luc Moreau,Judith Lengyel,Nicole Hauser,Roland Mory,Edilio Borroni,Emmanuel Pinard,Frédéric Knoflach,Götz Schlotterbeck,Dominik Hainzl,Joseph G. Wettstein +10 more
TL;DR: RG1678 is a potent, noncompetitive glycine reuptake inhibitor that can modulate both glutamatergic and dopaminergic neurotransmission in animal experiments that model aspects of schizophrenia.
Book ChapterDOI
NMR and MS methods for metabonomics
Frank Dieterle,Björn Riefke,Götz Schlotterbeck,Alfred Ross,Hans Martin Senn,Alexander Amberg +5 more
TL;DR: All important steps of metabolic profiling in drug development and molecular medicine are described in great detail, starting from sample preparation to determining the measurement details of all analytical platforms, and finally to discussing the corresponding specific steps of data analysis.
Journal ArticleDOI
Capillary HPLC-NMR coupling : High-resolution 1H NMR spectroscopy in the nanoliter scale
Beate Behnke,Götz Schlotterbeck,Ulrich Tallarek,Sabine Strohschein,Li-Hong Tseng,Tony Keller,Klaus Albert,Ernst Bayer +7 more
TL;DR: The coupling of gradient capillary HPLC with on-column, high-resolution NMR detection and on-line-detected NMR separation of dansylated amino acids is reported on.
Journal ArticleDOI
Metabolic profiling technologies for biomarker discovery in biomedicine and drug development.
TL;DR: The state-of-the-art of nuclear magnetic resonance spectroscopy, mass spectrometry and statistical tools for the acquisition and evaluation of complex multidimensional spectroscopic data in metabolic profiling is reviewed in this article.