G
Graeme Nixon
Researcher at University of Aberdeen
Publications - 64
Citations - 2232
Graeme Nixon is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Vascular smooth muscle & Religious education. The author has an hindex of 23, co-authored 62 publications receiving 2090 citations. Previous affiliations of Graeme Nixon include University of Virginia & Western Infirmary.
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Journal ArticleDOI
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle
Ming C. Gong,K. Iizuka,Graeme Nixon,J P Browne,A Hall,J F Eccleston,M Sugai,S Kobayashi,Avril V. Somlyo,Andrew P. Somlyo +9 more
TL;DR: It is concluded that p21rho may play a role in physiological Ca2+ sensitization as a cofactor with other messengers, rather than as a sole direct inhibitor of smooth muscle MLC20 phosphatase.
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Sphingolipids in inflammation: pathological implications and potential therapeutic targets.
TL;DR: A significant body of research now indicates that sphingolipids are intimately involved in the inflammatory process and recent studies have demonstrated that these lipids, together with associated enzymes and receptors, can provide effective drug targets for the treatment of pathological inflammation.
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Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles: Differential Role in Vasoconstriction
TL;DR: The ability of S1P to act as a vasoactive mediator is dependent on the activation of associated signaling pathways and may vary in different VSM, and differential signaling may be related to the expression of S 1P receptor subtypes.
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Immunogold localization of inositol 1,4,5-trisphosphate receptors and characterization of ultrastructural features of the sarcoplasmic reticulum in phasic and tonic smooth muscle.
TL;DR: It is concluded that InsP3 receptors are present in both the central and the peripheral sarcoplasmic reticulum of tonic and phasic smooth muscle, consistent with electron probe analysis results showing calcium release from both regions.
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Tumor Necrosis Factor-α–Induced Activation of RhoA in Airway Smooth Muscle Cells: Role in the Ca2+ Sensitization of Myosin Light Chain20 Phosphorylation
TL;DR: The TNF-induced increase in the Ca(2+) sensitivity of MLC(20) phosphorylation is through stimulation of the T NF-R1 receptor and via a RhoA/Rho-kinase pathway leading to inhibition of the myosin light chain phosphatase.