G
Graham M. Smith
Researcher at Merck & Co.
Publications - 22
Citations - 1417
Graham M. Smith is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Diels–Alder reaction. The author has an hindex of 13, co-authored 22 publications receiving 1363 citations.
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Journal ArticleDOI
Structure and Function of G Protein Coupled Receptors
Jelveh Lameh,Ric I. Cone,Sadaaki Maeda,Mohan Philip,Maithe Corbani,Laszlo Nadasdi,J. Ramachandran,Graham M. Smith,Wolfgang Sadee +8 more
TL;DR: This review summarizes the current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure.
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An alternative method for the alignment of molecular structures: Maximizing electrostatic and steric overlap
TL;DR: The SEAL method as discussed by the authors was developed to optimize the alignment of two three-dimensional structures using their atomic partial charges and steric volumes as factors, and this method will perform superimposition many times using randomly generated starting configurations and keep only the best unique results based on the value of the alignment function.
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Three-dimensional molecular modeling and drug design.
TL;DR: The computer-assisted molecular modeling system at Merck is described, and it is shown that this system is useful for generating and storing molecular structures, determining preferred conformation, comparing molecular shapes, and computing molecular properties.
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Computer program for the analysis of infrared spectra
Hugh B. Woodruff,Graham M. Smith +1 more
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A simple and efficient route to β-substituted pyrroles
TL;DR: The pyrrole ring undergoes Friedel-Crafts acylation exclusively at the β-position of the ring, thus allowing a simple and efficient synthesis of β-acylated pyrroles.