Showing papers by "Greg Fegan published in 2006"
TL;DR: The regime was moderately immunogenic, but the magnitude of T cell responses was lower than in previous studies, and future field studies will require vaccinations with stronger immunogenicity in children living in malarious areas.
Abstract: Objective: The objective was to measure the efficacy of the vaccination regimen FFM ME- TRAP in preventing episodes of clinical malaria among children in a malaria endemic area. FFM ME-TRAP is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara), which both deliver the pre-erythrocytic malaria antigen construct multiple epitope-thrombospondin-related adhesion protein (ME-TRAP).
141 citations
TL;DR: In children with severe malaria, a consistent survival benefit of receiving albumin infusion compared to other resuscitation fluids is shown, despite comparable effects on the resolution of acidosis and shock.
Abstract: Objectives: Previous studies have shown that in children with severe malaria, resuscitation with albumin infusion results in a lower mortality than resuscitation with saline infusion. Whether the apparent benefit of albumin is due solely to its colloidal properties, and thus might also be achieved with other synthetic colloids, or due to the many other unique physiological properties of albumin is unknown. As albumin is costly and not readily available in Africa, examination of more affordable colloids is warranted. In order to inform the design of definitive phase III trials we compared volume expansion with Gelofusine (succinylated modified fluid gelatin 4% intravenous infusion) with albumin.
99 citations